Douglas R Pedersen, Jessica E Goetz, Gail L Kurriger, James A MartinDepartment of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, USAPurpose: This study addresses the species-specific and site-specific details of weight-bearing articular cartilage zone depths and chondrocyte distributions among humans and common osteoarthritis (
Molecular interaction of TPPP with PrP antagonized the CytoPrP-induced disruption of microtubule structures and cytotoxicity.
BACKGROUND: Tubulin polymerization promoting protein/p25 (TPPP/p25), known as a microtubule-associated protein Beds (MAP), is a brain-specific unstructured protein with a physiological function of stabilizing cellular microtubular ultrastructures.Whether TPPP involves in the normal functions of PrP or the pathogenesis of prion disease remains unkno
Autophagy is inhibited by ubiquitin ligase activity in the nervous system
Despite growing interest in the role of autophagy in neurons, it remains unclear how this Door Hardware process is regulated, in particular, how autophagy is spatially restricted in subcellular compartments in neurons.In this study, the authors use an unbiased proteomic approach to show that the autophagy initiating kinase UNC-51/ULK and autophagos
Improving MR image quality with a multi-task model, using convolutional losses
Abstract Purpose During the acquisition of MRI data, patient-, sequence-, or hardware-related factors can introduce artefacts that degrade image quality.Four of the most significant tasks for improving MRI image quality have been bias field correction, super-resolution, motion-, and noise correction.Machine learning has achieved outstanding results